Package ‘ bear ’ July 21 , 2009

Title Average bioequivalence and bioavailability data analysis tool Author Hsin-ya Lee , Yung-jin Lee Maintainer Hsin-ya Lee Description An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental analysis (NCA), ANOVA (lm) for a standard RT/TR 2x2x2 crossover design and linear mixed effect model (lme of nlme) for a 2-treatment, 2-sequence, with 2 periods or more (i.e. 2x2x3/2x2x4) replicate design or a 2-treatment, 2-sequence, and 1-period parallel ABE study (2x2x1).